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Can Ozempic (Semaglutide) Make You Tired? Sleep MD Answers

Tiredness isn’t a common side effect of Ozempic, but this information comes from limited studies on diabetics. Research is lagging as more people use the drug.
Written by
Jeff Kahn, M.S., Rise Science Co-Founder
Reviewed by
Chester Wu, MD, Rise Science Medical Reviewer
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Can Ozempic (Semaglutide) Make You Tired? 

  • Tiredness is listed as a rare side effect of Ozempic and a more common side effect of the higher-dose version, Wegovy. It's not clear what dose of Ozempic causes tiredness nor whether this fatigue is ongoing, fleeting, or compared to how fatigued people felt before taking Ozempic.
  • It’s also not clear how Ozempic can cause tiredness. One theory is that by eating fewer calories, your body has less fuel and will feel tired as a result. You may also experience low blood sugar, leaving you low on energy. Ozempic may also affect your sleep, and adverse GI events — the most commonly listed side effect of the drugs — can easily cut into your sleep.
  • The RISE app can guide you through 20+ sleep hygiene habits each day to improve your sleep and energy levels while taking semaglutide drugs such as Ozempic or Wegovy (and even when you're not).

Ozempic — one brand name for the drug semaglutide — is a diabetes drug that’s often used for weight loss. It may cause tiredness as a side effect, but as it’s a relatively new drug, so more research is needed.

Below, we’ll dive into whether Ozempic can make you tired, other common side effects that could affect your sleep and energy, and how you can use the RISE app to get better sleep and more energy, both while on and off Ozempic.

Heads-up: More research needs to be done into Ozempic and its potential side effects. We’ve rounded up what we know so far, and we’ll update this article as more research comes out. While official research is lacking, there’s been an increase in online reports of Ozempic fatigue as more people start using the drug. 

Another heads-up: Ozempic, Wegovy, and Rybelsus are different versions of the same drug: semaglutide. Wegovy is a higher dose and Rybelsus is a tablet form. Here, we’ll focus on Ozempic, but we’ve covered whether Wegovy can make you tired here and whether Rybelsus can make you tired here. 

Advice From a Sleep Doctor

Advice From a Sleep Doctor

"Ozempic may cause fatigue as a side effect in some people. Evidence from a handful of clinical trials suggests it’s not common and it should resolve in time as your body gets used to the drug," says Dr. Chester Wu, Rise Science sleep advisor and medical reviewer, and a double board certified doctor in psychiatry and sleep medicine.

"If you’re feeling Ozempic fatigue, focus on eating a balanced diet, doing some gentle exercise, and catching up on any lost sleep Ozempic side effects cause with an afternoon nap or early night."

Does Ozempic Make You Feel Tired? 

Yes, Ozempic may make you feel tired. Tiredness isn’t listed as a common side effect of Ozempic, however. But this is just what we know from limited clinical trials. As popularity explodes, more people are reporting it online. Ozempic tiredness may get better as you adjust to the medication, but more research is needed.

According to the FDA, fatigue is a potential side effect of Ozempic, affecting more than 0.4% of people. This figure comes from clinical trials that looked at diabetics taking Ozempic, however, so it’s not clear how non-diabetics react to the drug. 

Also worth noting: fatigue is listed with dizziness and dysgeusia (a taste disorder) as a frequency of more than 0.4%, so it’s not clear if they all occur at more than 0.4% or if that’s the total frequency of all three side effects.

While 0.4% sounds like a small number, as Ozempic becomes increasingly popular, that 0.4% can end up being hundreds of thousands of people experiencing Ozempic fatigue. 

More recently, a first of its kind study, published in 2023 in Brain Sciences, analyzed social media posts about glucagon-like peptide-1 receptor agonists (GLP-1 receptor agonists) side effects, the class of medication Ozempic belongs to. It pulled together posts on Reddit, Youtube, and TikTok and found sleep-related issues were mentioned most by users, including mentions of insomnia, anxiety, depression, and general mental health issues. These findings come from social media, however, not controlled studies. 

There are a few more issues to consider here:

  • It’s not clear what dose of Ozempic could cause this fatigue. You’ll most likely be prescribed a low dose that will slowly increase over time, so the amount of fatigue you feel could change. 
  • It’s not clear whether this fatigue is ongoing, fleeting, or measured against fatigue levels before patients started taking Ozempic.

Tiredness is listed as a common side effect of Wegovy, however, which is simply a higher dose of the same drug: semaglutide. Fatigue affected 11% of people taking Wegovy in clinical trials. 

Heads-up: There’s a difference between tiredness and sleepiness. Tiredness is when you feel mentally or physically fatigued. Sleepiness is when you feel like you could fall asleep if you tried. You might feel tired after a workout, for example, but you might not be able to actually fall asleep. Ozempic may cause both tiredness, as a side effect, and sleepiness, as it can cause sleep deprivation. 

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Why Does Ozempic Make You Feel Tired? 

More research is needed to find out how Ozempic can make you feel tired. It’s thought Ozempic fatigue could be caused by eating fewer calories, low blood sugar, or gastrointestinal side effects or anxiety cutting into your sleep. New findings suggest Ozempic may affect dopamine levels, which could make you feel low, affecting your sleep and energy. 

Here’s more on why Ozempic could make you feel tired and sleepy:

  • Eating fewer calories: Ozempic reduces your appetite, so you eat fewer calories. As your body has less fuel, it can feel fatigued. A 2017 study found a once-a-week semaglutide injection led to a 24% reduction in calorie intake across the day. That’s quite a reduction! You may feel more drained if you’re not used to being in a caloric deficit or if you’ve started exercising more (which is recommended on Ozempic).
  • GI issues causing sleep loss: A 2023 review of studies on semaglutide listed “gastrointestinal adverse events” as the main side effects. These are reported by 5% or more of users. Adverse GI events, like diarrhea and stomach pain, can easily cut into your sleep. Beyond sleep loss, GI issues can leave you feeling mentally drained the longer you deal with them, and vomiting and diarrhea can cause dehydration, which causes fatigue. 
  • Anxiety causing sleep loss: Anxiety can make it harder to fall and stay asleep. In fact, RISE users say stress and anxiety are the biggest barriers to a good night’s sleep. If you’re taking Ozempic, you might feel anxiety around the drug itself, the GI issues it might cause you, your change in eating habits, potential drug interactions, or other side effects like hair loss or heart rate increase (and anxiety can spike your heart rate further). Research from 2023 found reports of semaglutide increasing anxiety, as well as triggering depression and even suicidal thoughts.   
  • Changes in dopamine making you feel low: Dopamine is a neurotransmitter linked to mood and motivation. Some 2023 research suggests semaglutide drugs could impact your brain’s dopamine reward system. This may lead to feeling less excitement and energy around food, or even in general. Low mood and anxiety can cause sleeplessness, but sleeplessness can worsen your mood and anxiety, creating a vicious circle. A lower mood may also be linked to lower alertness levels. 
  • Hypoglycemia (low blood sugar): You may experience hypoglycemia as a side effect, if you take Ozempic with other medications, drink alcohol, or do more exercise than usual. Hypoglycemia can cause drowsiness, restless sleep, shakiness, mood issues, and feeling weak. Nocturnal hypoglycemia (when your blood sugar drops too low overnight) can cause morning tiredness. Ozempic works to lower and control your blood sugar levels, so you may feel fatigue as your body gets used to lower blood sugar levels than you’re used to.
  • Hyperglycemia (high blood sugar): On the other end of the scale, you may experience hyperglycemia if you’re exercising less than usual or overeating (although this is hard to do on semaglutide). It can be hard to control your blood sugar levels when you’re diabetic, especially if semaglutide side effects like nausea cause you to delay or skip a meal. Hyperglycemia can also cause drowsiness. 
  • Exercising less: You may do less exercise than usual while on Ozempic, either because it makes you feel fatigued or perhaps GI issues are disrupting your usual routine. This lack of exercise can leave you feeling sluggish and it can make it harder to fall asleep at night. 
  • Increases in resting heart rate overnight, maybe: Ozempic can cause an increase in resting heart rate. Dr. Peter Attia, a renowned physician and longevity expert, says his practice has seen adults on semaglutide experiencing an increase of eight to 10 beats per minute in their overnight heart rate. It’s unclear how this increased heart rate from Ozempic could affect your sleep exactly, but the complex interaction between heart rate, autonomic nervous system activity, and sleep means this is an area where more research is needed.

It’s also possible that the more common culprits of tiredness (high sleep debt and circadian misalignment) are causing low energy, whether you’re taking semaglutide or not. We’ll get into how to fix these next.

Heads-up: Many studies on Ozempic include people with diabetes, so we don’t know much about how the drug affects the general population — like those using it for weight loss when they’re not diabetic, for example. 

Ozempic may be used for other health conditions, like cancer and alcohol and opioid addiction. But more research is needed to find out how the drug affects the sleep and energy of people with these conditions, and how their various medications interact with Ozempic. 

Does Semaglutide Make You Feel Tired?

Semaglutide may make you feel tired. It’s listed as a potential side effect of some medications that contain the drug, including Ozempic and Wegovy. 

More research is needed to know why semaglutide can make you feel tired, but it could be down to eating fewer calories, GI issues and anxiety causing sleep loss, low or high blood sugar, and doing less exercise than usual.   

Fatigue isn’t listed as a side effect of Rybelsus, however, which are daily semaglutide tablets. But Rybelsus can cause side effects — like nausea and abdominal pain — which could cause sleep loss.

We’ve also covered whether dual-acting GLP-1/GIP receptor agonists for type 2 diabetes and weight loss (active ingredient: tirzepatide) — like Mounjaro and Zepbound— make you feel tired.

Does Ozempic Affect Sleep? 

Ozempic may affect your sleep, either directly or through the side effects and behavior changes it can cause. 

For example, GI issues — and the stress they cause — can make it hard to get enough sleep. Skipping workouts may make it harder to fall asleep and low blood sugar from eating less may wake you up in the night.   

Ozempic may also worsen anxiety and depression, which can cause sleep loss, which, in turn, can make anxiety and depression worse. 

Ozempic may affect your sleep directly, but more research is needed. A clinical trial company called eHealthMe looked into sleep problems in those taking Ozempic. It states poor quality sleep was reported in those taking the drug, especially by “people who are female, 60+ old, have been taking the drug for 6 - 12 months.” 

The company helps the public run clinical trials, however, and data is sparse. Plus, there’s no set definition for sleep quality, so we don’t really know how Ozempic affected their sleep exactly. 

But it’s not all bad news. 

Can Ozempic Improve Your Sleep? 

Ozempic may improve your sleep by helping you lose weight or manage type 2 diabetes, which then improves sleep problems caused by these health conditions. Both type 2 diabetes and obesity are linked to sleep disturbances and sleep disorders like sleep apnea

We’ve covered more on Ozempic as a potentially promising treatment for sleep apnea here. 

Ozempic may improve other conditions caused by diabetes, like joint pain, which can disrupt sleep.

And the 2023 study we mentioned earlier looking into social media reports found some Ozempic users reported improved insomnia, as well as improved anxiety and depression, which may in turn improve your sleep.

The diet and exercise changes that are encouraged when taking Ozempic can also help you sleep. Ozempic may also reduce food cravings, appetite, and preference for high-fat foods, so you eat better and smaller meals. This too can improve your sleep. 

Ozempic may even reduce your cravings for alcohol and cigarettes, and cutting down on these can also improve your sleep. 

Does Ozempic Cause Insomnia?

It’s unclear whether Ozempic can cause insomnia. A 2023 study found social media reports of GLP-1 receptor agonists like Ozempic causing insomnia, but it also found reports of improved insomnia. 

This research also found users reporting better and worse anxiety and depression, both of which are linked to insomnia. 

This shows, again, how much more research is needed into Ozempic.

Ozempic may cause sleep problems that look a lot like insomnia, but they may not be clinical insomnia. 

According to the third edition of the International Classification of Sleep Disorders (ICSD-3), insomnia is when you have: 

  • Difficulty falling asleep or staying asleep, or waking up too early 
  • Difficulty sleeping despite having the opportunity to sleep 
  • Daytime impairment or distress from sleep problems 
  • Sleep problems that are not better explained by another sleep disorder or medical condition

Having these sleep problems at least three nights a week for at least three months could be a sign of insomnia. Having them for one to three months could be a sign of episodic insomnia.

Chronic or episodic insomnia may need different, or additional, treatments compared to other sleep problems caused by Ozempic. Seek medical advice if you think you have insomnia. 

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How Long Does Ozempic Fatigue Last? 

It’s unclear how long Ozempic fatigue lasts. Ozempic fatigue may last for a few weeks while your body gets used to the medication and while your dose is increasing. 

From what we know so far, Ozempic-related fatigue does go away after the initial adjustment period as the body gets accustomed to the medication.

Fatigue may be caused by other factors, however, so how long it lasts can vary. For example, if GI issues are causing sleep loss, but these resolve in a few week’s time, your Ozempic fatigue may resolve in a few weeks, too. 

There are no long-term studies on Ozempic, however, so we don’t know if it causes fatigue when you take it for long periods of time or when exactly Ozempic fatigue goes away.

Ozempic can lower your blood sugar levels within the first week of use, but it can take eight weeks or longer for the medication to reach its full effect. So you may feel fatigue creep up in this time.

What Are the Side Effects of Ozempic? 

The most common side effects of Ozempic include: 

  • Nausea 
  • Diarrhea 
  • Constipation 
  • Vomiting 
  • Cramping 
  • Acid reflux 
  • Abdominal pain
  • Burping 
  • Bloating 
  • Swelling at the injection site 
  • Hair loss 
  • Less fullness in the face and more visible wrinkles 
  • Tiredness 

Many of these side effects — like nausea and diarrhea — can make it hard to get enough sleep.

Ozempic is still a relatively new drug, so we don’t know the full extent of the side effects, or the long-term effects of taking it.

Research from 2021 into semaglutide found most of these symptoms were mild or moderate, and got better over time without patients needing to stop the medication. But everyone reacts differently, and it may take five weeks or longer for side effects to clear up once you stop taking the drug.  

More serious possible side effects of semaglutide include: 

  • Inflammation of the pancreas (pancreatitis) 
  • Changes in vision 
  • Kidney problems or kidney failure 
  • Serious allergic reactions 
  • Low blood sugar levels (when taken with other medications)
  • Gallbladder disease 
  • Diabetic retinopathy complications 
  • Potential increased risk of thyroid cancer — semaglutide causes thyroid tumors in animals, but more human research is needed.

These side effects happen in rare cases. Seek medical attention if you get serious side effects from Ozempic. Ozempic isn’t used to treat type 1 diabetes, and it's not clear if Ozempic is safe for those who are pregnant or breastfeeding. Get medical advice before taking these drugs. 

One major problem with Ozempic research? Most of what we know about the drugs comes from studies linked to the manufacturer, Novo Nordisk. More research needs to be done.

How to Improve Ozempic Fatigue?

You can improve Ozempic fatigue by lowering your sleep debt, syncing up with your circadian rhythm, improving your sleep hygiene, managing GI issues, reducing anxiety, eating a balanced diet, and getting some exercise.

Here’s more on how to feel less tired on Ozempic. 

Lower Your Sleep Debt

Sleep debt is the running total of how much sleep you owe your body. The more sleep debt you have — whether it’s caused by Ozempic or not — the more tired and sleepy you’re going to feel.

You can lower your sleep debt to get more energy. Here’s how: 

  • Take a nap: If GI issues disrupt your sleep at night, consider taking a nap to catch up on shut-eye. Check RISE for the best time to do this to stop daytime naps from keeping you awake at night.
  • Go to bed a little earlier
  • Sleep in a little later: Keep lay-ins to an hour or so to avoid messing up your circadian rhythm (more on that soon). 
  • Improve your sleep hygiene: Sleep hygiene habits can cut down the time it takes you to fall asleep and reduce how often you wake up during the night, helping you get more sleep overall. More on what to do soon.

RISE works out how much sleep debt you have and keeps track of it as you pay it back. Aim to keep your sleep debt to five hours or less to feel more energy each day. 

RISE app screenshot showing how much sleep debt you have
The RISE app can work out how much sleep debt you have.

RISE calculates your sleep debt by comparing how much sleep you get to how much sleep you need. This is known as your sleep need — which is determined by genetics and is unique to you. 

For example, when we looked at the sleep needs of 1.95 million RISE users aged 24 and up, we found it ranged from five hours to 11 hours 30 minutes. 

The RISE app can tell you how much sleep you need
RISE works out how much sleep you need.

RISE users on iOS 1.202 and above can click view their sleep need here and view their sleep debt here.

Get in Sync With Your Circadian Rhythm

Your circadian rhythm is your body’s roughly 24-hour biological clock. You can feel tired and have trouble sleeping if you’re living out of sync with it — which can happen if you work night shifts, have an irregular sleep schedule, or eat at odd times. 

Get in sync with your circadian rhythm by: 

  • Going to bed and waking up at the same time every day of the week. 
  • Eating meals at roughly the same times and not too close to bedtime or during the night. 
  • Going to bed during your Melatonin Window — which is what we call the roughly one-hour window of time when your body’s rate of melatonin production (the sleep hormone) is at its highest. 

RISE predicts the timing of your circadian rhythm each day so you can better sync up your sleep and meal times to match. 

Expert tip: Your energy levels naturally fluctuate across the day. Check RISE for when you can expect peaks in energy and plan your day to match to make the most of the energy you do have while on Ozempic. 

RISE app screenshot showing your energy schedule
The RISE app predicts the timing of your circadian rhythm.

RISE users on iOS 1.202 and above can see their circadian rhythm on the Energy screen here

Improve Your Sleep Hygiene 

Sleep hygiene is the set of habits you can do daily to fall asleep more quickly, wake up less often during the night, and get the most restorative sleep possible, both when you’re taking Ozempic and if you come off the drug. 

Here’s what to do: 

  • Get at least 10 minutes of natural light exposure as soon as possible after waking up. If it’s overcast or you’re getting light through a window, make that 15 to 20 minutes.
  • Dim the lights and put on blue-light blocking glasses 90 minutes before bed.
  • Avoid caffeine, large meals, vigorous exercise, and alcohol too late in the day (some of these may happen more naturally while on Ozempic).
  • Keep your bedroom dark, cool, and quiet.

RISE can guide you through 20+ sleep hygiene habits each day and tell you the ideal time to do each one to make them more effective.

RISE app screenshot showing sleep hygiene habit reminders
The RISE app can guide you through daily sleep hygiene behaviors.

RISE users on iOS 1.202 and above can set up their 20+ in-app habit notifications here.  

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Manage GI Issues 

If GI issues are keeping you up, here are some Ozempic fatigue remedies to try: 

  • Eat bland, easily digestible foods like toast, rice, and bananas.
  • Avoid anything fried, spicy, and fatty.
  • Eat smaller, more frequent meals. 
  • Eat ginger or drink ginger tea if you’re feeling nauseous.
  • Stay hydrated if Ozempic causes vomiting and diarrhea (and at all times). 
  • Try sleeping on your left side if you have acid reflux. A 2022 study found left-side sleeping helped people have more reflux-free nights. Sleeping on your side may also help if you have cramps as you’re not putting pressure on your painful stomach area.

We’ve got tailored advice for some common GI issues such as:  

Reduce Anxiety 

It’s easier said than done, but try to keep anxiety in check, especially before bed. 

If you can’t sleep, avoid looking at the time and worrying about how few hours there are before your alarm clock goes off. 

Breathing exercises and relaxation techniques can help reduce stress and anxiety. RISE’s audio guides can walk you through relaxation techniques to help lower anxiety so you can drift off. 

Expert tip: If you’ve been awake in bed for more than 20 minutes, get up and do a relaxing activity in low lighting until you feel sleepy again. This will stop your brain from making a link between your bed and wakefulness.

We’ve covered more on how to sleep with anxiety here.

Eat a Balanced Diet

Your appetite may change on Ozempic and you may find yourself having fewer food cravings. But you should still strive to eat a balanced diet overall — this can help boost your energy and improve your sleep. 

Eat plenty of fruits, veggies, fiber-rich complex carbs, and protein. Research shows semaglutide can reduce muscle mass, so a high-protein diet can help stave this off. 

We’ve covered more on foods that give you energy here. 

Get Some Exercise

You may not feel like exercising if you’re fatigued and nauseous, but try to get in some physical activity each day — even if it’s just a walk or some gentle yoga.

Exercise can help you fall asleep faster, wake up less often, and improve insomnia. It’ll also boost your energy. Just be sure not to do any vigorous exercise within an hour of bedtime as this can keep you up. 

We’ve covered more on the best time to work out here.

Speak to a Healthcare Provider 

Speak to a healthcare professional if you’re taking Ozempic and suffering from fatigue. They can suggest treatment options tailored to you. 

They may lower the dose of other prescription drugs or supplements you’re taking or suggest over-the-counter medications to help with GI side effects. 

They may also recommend taking Ozempic at a different time of day, like in the morning as opposed to before bed, to see if that stops side effects from disrupting your sleep. Drug timing may make a difference — the emerging field of chronopharmacology shows there’s likely an optimal time of day to take medication, like the flu shot, for example.

We’ve covered more ways to get more energy here.

Get Over Ozempic Fatigue

If you’re taking Ozempic, there’s a chance the drug could be causing fatigue. As far as we know, this side effect is rare, however, and it may improve with time. More research is needed into the potential side effects to know for sure. 

To feel less tired on Ozempic, eat a balanced diet, get some exercise, and manage GI issues and anxiety. Focus on paying down your sleep debt and getting in sync with your circadian rhythm for a real energy boost. RISE works out how much sleep debt you have and shows you a prediction of your circadian rhythm each day to help. 

You can also follow RISE’s 20+ sleep hygiene recommendations to have an easier time falling and staying asleep.

RISE users say these habit reminders make a big difference: 

“Just becoming more aware of when’s the best time to drink caffeine, eat dinner and get sunlight according to my circadian rhythm has helped my sleep quality tremendously.” Read the review.

And it’s not better nights — 80% of RISE users feel more daytime energy within five days. 

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